Senior Manager Clinical Operations – Early Development Job at High Wycombe Full Time NEW

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

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As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:
R&D Operations
Job Sub Function:
Clinical Trial Project Management
Job Category:
Professional
All Job Posting Locations:
High Wycombe, Buckinghamshire, United Kingdom
Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at

We are searching for the best talent for a Senior Manager Clinical Operations for Early Development & Clinical Pharmacology (ED&CP) accountable for strategic and operational management, and successful country execution of Early Development and/or Clinical Pharmacology (phase 0-IIa) trials across multiple therapeutic areas, including resource allocation, adherence to timelines and budget, compliance with relevant SOPs, policies, Health Care Compliance, and local regulatory requirements.

This is a Hybrid position (3 days per week onsite, 2 days WFH) located within commutable distance of High Wycombe, United Kingdom. (

Note:

J&J office relocates to Maidenhead, UK in October 2026).

Purpose:

The Senior Manager Clinical Operations, Early Development is accountable for shaping and managing local and regional organizational ED&CP structure to ensure its optimal efficiency and demonstrates an effective issue management. This individual is responsible for line management of Trial Managers (TMs) Early Development, Site Managers (SMs) Early Development, Clinical Trial Assistants (CTAs) and/or other GCO staff as required including junior Functional Managers.

Oversees staff performance, development, training, project assignments, workload distribution and supports issue resolution with direct reports. Ensures alignment of local goals with organizational objectives. Drives innovative solutions and process improvements for ED&CP and GCO/GD overall. Ensures mentoring/managing of more junior Managers and can assume cross border oversight.

Are you interested to join our team? Then please read further!

You will be responsible for:

• Providing line management to direct reports, including setting goals and objectives, conducting performance evaluations, and supporting talent development.
• Evaluating and forecasting resource needs for the assigned portfolio and coordinating plans with the Director, Early Development (EMEA/Americas).
• Supporting the flexible resourcing model by collaborating with Flex Resource managers to recruit, onboard, offboard, and assess flex staff performance.
• Interviewing, hiring, training, and developing team members.
• Ensuring understanding of relevant processes and procedural documents, and maintaining documented training compliance for direct reports.
• Supporting direct reports in issue resolution and stakeholder communications with Ethics Committees, Health Authorities, investigational sites, and study teams.
• Supporting local implementation of organizational changes and communicating priority shifts clearly.
• Reviewing and approving expenses in compliance with company policies.
• Demonstrating leadership behaviors aligned with J&J Leadership Imperatives.
• Fostering an environment that encourages sharing of ideas, information, and best practices internally and externally.
• Providing coaching and mentorship, including conducting accompanied site visits as appropriate.
• Defining and delivering long-term strategy aligned with Global Development, ED&CP, and Innovative Medicine strategies to position local and regional ED&CP for success.
• Attracting, planning, executing, and monitoring ED&CP clinical trials (feasibility to close-out) and maintaining inspection readiness for the portfolio.
• Ensuring operational objectives are met in conformance with ICH-GCP, relevant SOPs, and other procedural documents.
• Escalating and reporting suspected fraud, scientific or ethical misconduct, and healthcare compliance breaches, and contributing to CAPA and timely issue resolution.
• Shaping and maintaining strong relationships within ED&CP, the local GCO department, the Country…